Vol. 19 (2020)

Published continuously

Published: 2020-01-02

Original articles

The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema

Saeideh Vafa, Shahpar Haghighat, Leila Janani, Ali Saneei Totmaj, Mehraban Navaei, Ali Amirinejad, Hadi Emamat, Zahra Salehi, Mitra Zarrati

1-15
5,6,7,4’-Tetramethoxyflavanone protects against neuronal degeneration induced by dexamethasone by attenuating amyloidogenesis in mice

Kanet Pakdeepak, Ratchanaporn Chokchaisiri, Jiraporn Tocharus, Pranglada Jearjaroen, Chainarong Tocharus, Apichart Suksamrarn

16-32
Effect of Ficus glomerata leaf extract in streptozotocin-induced early diabetic complications and its characterization by LC-MS

Abusufyan Sirajuddin Shaikh, Mohammad Ibrahim, Mohib Khan, Dr.

33-47
Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives

Milena D. Vukic, Nenad L. Vukovic, Ana Obradovic, Milos Matic, Maja Djukic, Edina Avdovic

48-70
Phosphoinositide 3-kinase inhibitor AS605240 ameliorates streptozotocin-induced Alzheimer’s disease like sporadic dementia in experimental rats

Ramesh Alluri, Siva Mallikarjuna Reddy Ambati, Kasiviswanath Routhu, Spandana Rajendra Kopalli, Sushruta Koppula

71-85
RNA-protein correlation of liver toxicity markers in HepaRG cells

Albert Braeuning, Almut Mentz, Felix F. Schmidt, Stefan P. Albaum, Hannes Planatscher, Jörn Kalinowski, Thomas O. Joos, Oliver Poetz, Dajana Lichtenstein

135-153
Common transcriptional programs and the role of chemokine (C-C motif) ligand 20 (CCL20) in cell migration of cholangiocarcinoma

Hay Mar Win Maung, Waraporn Chan-On, Nawapol Kunkeaw, Prasong Khaenam

154-166
CRISPR/Cas9-mediated knockout of MLL5 enhances apoptotic effect of cisplatin in HeLa cells in vitro

Mohammad Pirouzfar, Farshid Amiri, Mehdi Dianatpour, Mohammad Ali Takhshid

170-182
The safety evaluation of FM101, an A3 adenosine receptor modulator, in rat, for developing as therapeutics of glaucoma and hepatitis

Chong-Woo Park, Chung-Tack Han, Yasue Sakaguchi, Jiyoun Lee, Hwa-Young Youn

187-200
Association of biofilm formation with multi drug resistance in clinical isolates of Pseudomonas aeruginosa

Nazia Abdulhaq, Zeeshan Nawaz, Muhammad Asif Zahoor, Abu Baker Siddique

201-208
Rational design of novel coumarins: A potential trend for antioxidants in cosmetics

Apilak Worachartcheewan, Veda Prachayasittkul, Supaluk Prachayasittkul, Visanu Tantivit, Chareef Yeeyahya, Virapong Prachayasittkikul

209-226
Short term effects of coffee components consumption on gut microbiota in patients with non-alcoholic fatty liver and diabetes: A pilot randomized placebo-controlled, clinical trial

Asieh Mansour, Mohammad Reza Mohajeri-Tehrani, Sara Karimi, Milad Sanginabadi, Hossein Poustchi, Samaneh Enayati, Saeedeh Asgarbeik, Javad Nasrollahzadeh, Azita Hekmatdoost

241-250
Effect of grape polyphenols on selected inflammatory mediators: A systematic review and meta-analysis randomized clinical trials

Fahimeh Haghighatdoost, Ali Gholami, Mitra Hariri

251-267
Tumor-derived urinary exosomal long non-coding RNAs as diagnostic biomarkers for bladder cancer

Maryam Abbastabar, Mohammad Sarfi, Abolfazl Golestani, Ali Karimi, Gholamreza Pourmand, Ehsan Khalili

301-310
Possible involvement of the opioidergic system in the modulation of body temperature, jumping behavior and memory process in cholestatic and addicted mice

Mohammad-Reza Zarrindast, Yasaman Issazadeh, Niloofar Rezaei, Fatemeh Khakpai

311-322
Antitrypanosomal butanolides from Aiouea trinervis

Felipe Oliveira Nunes, Júlio Menta de Almeida, Alda Maria Teixeira Ferreira, Letícia Alves da Cruz, Camila Mareti Bonin Jacob, Walmir Silva Garcez, Fernanda Rodrigues Garcez

323-333
The small chain fatty acid butyrate antagonizes the TCR-stimulation-induced metabolic shift in murine epidermal γδ T cells

Lukas Häselbarth, D. Margriet Ouwens, Nadine Teichweyde, Katrin Hochrath, Katja Merches, Charlotte Esser

334-350
Involvement of haptoglobin phenotypes and genotypes in non-muscle invasive bladder cancer: A possible prognostic marker for risk stratification

Nazi Aghaalikhani, Mojtaba Zamani, Abdolamir Allameh, Amir Mashayekhi, Pejman Shadpour, Marzieh Mahmoodi, Nadereh Rashtchizadeh

351-359
Broad-spectrum antimicrobial activity of wetland-derived Streptomyces sp. ActiF450

Mabrouka Benhadj, Roumaisa Metrouh, Taha Menasria, Djamila Gacemi-Kirane, Fatma Zohra Slim, Stephane Ranque

360-371
The effects of occupational exposure to manganese fume on neurobehavioral and neurocognitive functions: An analytical cross-sectional study among welders

Younes Mehrifar, Mahshid Bahrami, Esmail Sidabadi, Hamideh Pirami

372-386
Role of Kupffer cells in liver injury induced by CpG oligodeoxynucleotide and flucloxacillin in mice

Yuying Gao, Binbin Song, Shigeki Aoki, Kousei Ito

387-399
Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target

Joseph Thomas Ortega, Maria Luisa Serrano, Flor Helene Pujol, Hector Rafael Rangel

400-409
Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis

Joseph Thomas Ortega, Maria Luisa Serrano, Flor Helene Pujol, Hector Rafael Rangel

410-417
Toxic responses of the liver and kidneys following occupational exposure to anesthetic gases

Masoud Neghab, Fatemeh Amiri, Esmaeel Soleimani, Saeed Yousefinejad, Jafar Hassanzadeh

418-429
Analysis of Natural Killer cell functions in patients with hereditary hemochromatosis

Vivian Bönnemann, Maren Claus, Barbara Butzeck, Daniela Collette, Peter Bröde, Klaus Golka, Carsten Watzl

430-441
Hygrophorus eburneus, edible mushroom, a promising natural bioactive agent

Marijana M. Kosanić, Dragana S. Šeklić, Milena M. Jovanović, Nevena Petrović, Snežana D. Marković

442-457
QSAR-driven rational design of novel DNA methyltransferase 1 inhibitors

Chuleeporn Phanus-umporn, Veda Prachayasittikul, Chanin Nantasenamat, Supaluk Prachayasittikul, Virapong Prachayasittikul

458-475
Association between HIC1 promoter methylation and solid tumor: A meta-analysis

Zhao Tie, Justice Afrifa, Dong Wang, Jingcui Yu

476-489
Silver nanoparticles restrict microbial growth by promoting oxidative stress and DNA damage

Oluyomi Stephen Adeyemi, Emmanuella Oluwatosin Shittu, Oghenerobor Benjamin Akpor, Damilare E. Rotimi, Gaber El-saber Batiha

492-500
Urinary PCA3 detection in prostate cancer by magnetic nanoparticles coupled with colorimetric enzyme-linked oligonucleotide assay

Vichanan Yamkamon, Khin Phyu Pyar Htoo, Sakda Yainoy, Thummaruk Suksrichavalit, Tienrat Tangchaikeeree, Warawan Eiamphungporn

501-513
Toxoplasma gondii: Preventive and therapeutic effects of morphine and evaluation of treatment parameters of tachyzoites and infected macrophages in vitro and in a murine model

Leila Zaki, Fatemeh Ghaffarifar, Zohreh Sharifi, John Horton, Javid Sadraei

514-527
Perifosine and vitamin D combination induces apoptotic and non-apoptotic cell death in endometrial cancer cells

Meryem Ilkay Karagul, Savas Aktas, Sakir Necat Yilmaz, Derya Yetkin, Havva Didem Celikcan, Ozge Selin Cevik

532-546
The neural basis of hazard perception differences between novice and experienced drivers - An fMRI study

Seifollah Gharib, Arash Zare-Sadeghi, Seyed Abolfazl Zakerian, Mohsen Reza Haidari

547-566
Fibroblast Growth Factor–21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells

Yeboah Kwaku Opoku, Zhihang Liu, Justice Afrifa, Asare Kwame Kumi, Han Liu, George Ghartey-Kwansah, Harriet Koranteng, Xinghao Jiang, Guiping Ren, Deshan Li

567-581
Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway

Chawalit Chatupheeraphat, Chanin Nantasenamat, Kamolchanok Deesrisak, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyong

582-595
Synergistic effects of quercetin and regular exercise on the recovery of spatial memory and reduction of parameters of oxidative stress in animal model of Alzheimer's disease

Amin Molaei, Homeira Hatami, Gholamreza Dehghan, Reihaneh Sadeghian, Nazli Khajehnasiri

596-612
Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway

Faiz Ahmad, Amit Sarder, Rajesh Gour, Shibendra Kumar Lal Karna, Priya Arora, P. Ravindranathan Kartha, Yuba Raj Pokharel

613-619
Aloin promotes cell apoptosis by targeting HMGB1-TLR4-ERK axis in human melanoma cells

Pan Li, Kai Ren, Yin yin Liang, Ji kai Liu, Zhuo wen Liang, Yong feng Zhang

641-651
Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial

Masoumeh Khalighi Sikaroudi, Marjan Mokhtare, Farzad Shidfar, Leila Janani, AmirHossein Faghihi Kashani, Mohsen Masoodi, Shahram Agah, Afsaneh Dehnad, Shahrzad Shidfar

652-667
The methanolic extract of Cinnamomum zeylanicum bark improves formaldehyde-induced neurotoxicity through reduction of phospho-tau (Thr231), inflammation, and apoptosis

Sara Sayad-Fathi, Arash Zaminy, Parvin Babaei, Fatemeh Yousefbeyk, Nasibeh Azizi, Ebrahim Nasiri

671-686
Microbiological and virulence aspects of Rhodotorula mucilaginosa

Isabele Carrilho Jarros, Flávia Franco Veiga, Jakeline Luiz Corrêa, Isabella Letícia Esteves Barros, Marina Cristina Gadelha, Morgana F. Voidaleski, Neli Pieralisi, Raissa Bocchi Pedroso, Vânia A. Vicente, Melyssa Negri, Terezinha I Estivalet Svidzinski

687-704
Molecular mechanism and health effects of 1,2-Naphtoquinone

Antonio Garcia Soares, Marcelo N. Muscara, Soraia K. P. Costa

707-717
Proteomics profiling asthma induced-lysine acetylation

Xin-ming Su, Yuan Ren, Meng-lu Li, Shi-yao Bai, Na Yu, Ling-fei Kong, Jian Kang

734-744
Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics

Toktam Sadat Tavabe Ghavami, Shiva Irani, Reza Mirfakhrai, Reza Shirkoohi

750-761
Aerobic training and hydroalcoholic extracts of green tea improve pro-oxidant-antioxidant balance and histopathological score in the N-methyl-N-nitrosourea-induced prostate cancer model of rat

Zakaria Vahabzadeh, Mohammadraman Molodi, Bahram Nikkho, Marziyeh Saghebjoo, Saber Saedmocheshi, Fatemeh Zamani, Yazdan Roshani, Sina Babanzadeh

762-772
Tumor mutation burden associated with miRNA-gene interaction outcome mediates the survival of patients with liver hepatocellular carcinoma

Qing-Jiang Yu, Yi-Zhi Liang, Xiao-Ping Mei, Tai-Yong Fang

861-871
Roles of kininogen-1, basement membrane specific heparan sulfate proteoglycan core protein, and roundabout homolog 4 as potential urinary protein biomarkers in diabetic nephropathy

Piyada Na Nakorn, Supitcha Pannengpetch, Patcharee Isarankura-Na-Ayudhya, Chadinee Thippakorn, Ratana Lawung, Nuankanya Sathirapongsasuti, Chagriya Kitiyakara, Piyamitr Sritara, Prin Vathesatogkit, Chartchalerm Isarankura-Na-Ayudhya

872-891
Induction and repression effects on CYP and transporter protein abundance by azole mixture uptake in rat liver

Helen Hammer, Flavia Schmidt, Tanja Heise, Constanze Knebel, Alexander Dabrowski, Hannes Planatscher, Carsten Kneuer, Philip Marx-Stoelting, Oliver Pötz

904-916
Significance of E-cadherin and Vimentin as epithelial-mesenchymal transition markers in colorectal carcinoma prognosis

Zohreh Niknami, Ahad Muhammadnejad, Alireza Ebrahimi, Zahra Harsani, Reza Shirkoohi

917-926
The therapeutic potential of losartan in lung metastasis of colorectal cancer

Milad Hashemzehi, Niloufar Naghibzadeh, Fereshteh Asgharzadeh, Asma Mostafapour, Seyed Mahdi Hassanian, Gordon A. Ferns, William C. Cho, Amir Avan, Majid Khazaei

927-935
Phenoxodiol sensitizes metastatic colorectal cancer cells to 5-fluorouracil- and oxaliplatin-induced apoptosis through intrinsic pathway

Esra Yaylaci, Hacer Ilke Onen, Atiye Seda Yar Saglam

936-949
Microglia enhances proliferation of neural progenitor cells in an in vitro model of hypoxic-ischemic injury

Supanee Chounchay, Stephen C. Noctor, Nuanchan Chutabhakdikul

950-961
Octyl gallate induces hepatic steatosis in HepG2 cells through the regulation of SREBP-1c and PPAR-γ gene expression

Kelly Goulart Lima, Vitor Giancarlo Schneider Levorse, Maria Claudia Rosa Garcia, Bruno de Souza Basso, Bruna Pasqualotto Costa, Géssica Luana Antunes, Carolina Luft, Gabriela Viegas Haute, Léder Leal Xavier, Márcio Vinícius Fagundes Donadio, Jarbas Rodrigues de Oliveira

962-971
Effect of sodium butyrate on HDAC8 mRNA expression in colorectal cancer cell lines and molecular docking study of LHX1 - sodium butyrate interaction

Flora Forouzesh, Mahsa Ghiaghi, Hamzeh Rahimi

1038-1051
Development of a novel in vitro assay to evaluate environmental water using an IL-8 reporter cell line

Yutaka Kimura, Chizu Fujimura, Toshifumi Imagawa, Socorro P. Lupisan, Mariko Saito-Obata, Mayuko Saito, Hitoshi Oshitani, Setsuya Aiba

1054-1063
Exosomes derived from human mesenchymal stem cells preserve mouse islet survival and insulin secretion function

Somayeh Keshtkar, Maryam Kaviani, Fatemeh Sabet Sarvestani, Mohammad Hossein Ghahremani, Mahdokht Hossein Aghdaei, Ismail H. Al-Abdullah, Negar Azarpira

1064-1080
Cytoprotective effects of fermented oyster extracts against oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling pathway in MC3T3-E1 osteoblasts

Cheol Park, Hyesook Lee, Min Ho Han, Jin-Woo Jeong, Sung Ok Kim, Soon-Jeong Jeong, Bae‐Jin Lee, Gi‐Young Kim, Eui Kyun Park, You‐Jin Jeon, Yung Hyun Choi

1102-1119
LncRNA HOTAIR promotes MPP+-induced neuronal injury in Parkinson’s disease by regulating the miR-874-5p/ATG10 axis

Jingya Zhao, Hongli Li, Na Chang

1141-1153
Association between resilience and a functional polymorphism in the serotonin transporter (SLC6A4) gene: A meta-analysis

Yeimy González-Giraldo, Diego A. Forero

1174-1183
Plasma vascular endothelial growth factor B is elevated in non-alcoholic fatty liver disease patients and associated with blood pressure and renal dysfunction

Xiaofeng Ye, Wen Kong, Mohammad Ishraq Zafar, Junchao Zeng, Rui Yang, Lu-Lu Chen

1186-1195
Curcumin as an indirect methylation inhibitor modulates the effects of Toxoplasma gondii on genes involved in male fertility

Jasem Saki, Mohamad Sabaghan, Reza Arjmand, Ali Teimoori, Mohammad Rashno, Ghasem Saki, Saeedeh Shojaee

1196-1207
Knockdown of CSNK2β suppresses MDA-MB231 cell growth, induces apoptosis, inhibits migration and invasion

Shibendra Kumar Lal Karna, Bilal Ahmad Lone, Faiz Ahmad, Nerina Shahi, Yuba Raj Pokharel

1211-1226
Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Syarifah Aisyah Syed Abdul Halim, Nahdia Afiifah Abdul Jalil, Nor Haliza Mohamad Najib, Seong Lin Teoh, Siti Balkis Budin

1246-1265
Assessment of trimethylamine-N-oxide at the blood-cerebrospinal fluid barrier: Results from 290 lumbar punctures

Dietmar Enko, Sieglinde Zelzer, Tobias Niedrist, Sandra Holasek, Andreas Baranyi, Wolfgang J. Schnedl, Markus Herrmann, Andreas Meinitzer

1275-1281
Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell lines

Serag Eldin I. Elbehairi, Ahmed Ezzat Ahmed, Ali A. Alshati, Mohammed A. Al-Kahtani, Mohammad Y. Alfaifi, Khalid M. Alsyaad, Ali Yahya A. Alalmie, Mohammed M. Elimam Ahamed, Mahmoud F. Moustafa, Sadeq K. Alhag, Ahmed M. Al-Abd, Ahmed M. Abbas

1282-1294
Negative impact of COVID-19 pandemic on sleep quantitative parameters, quality, and circadian alignment Implications for health and psychological well-being

Mohammad Ali Salehinejad, Maryam Majidinezhad, Elham Ghanavati, Sahar Kouestanian, Carmelo M. Vicario, Michael A. Nitsche, Vahid Nejati

1297-1308
The association of a genetic variant in CDKN2A/B gene and the risk of colorectal cancer

Farzad Rahmani, Amir Avan, Forouzan Amerizadeh, Gordon A. Ferns, Sahar Talebian, Soodabeh Shahidsales

1316-1321
In vitro anticancer activity of Scrophularia amplexicaulis extracts on MCF-7 and WEHI-164 cell line

Samira Valiyari, Elham Beiranvand, Azin Samimi, Saeid Yaripour, Behzad Baradaran, Abbas Delazar, Mehdi Forouzesh

1341-1352
Differential engulfment of Staphylococcus aureus and Pseudomonas aeruginosa by monocyte-derived macrophages is associated with altered phagocyte biochemistry and morphology

Mohamed El Mohtadi, Lisa Pilkington, Christopher M. Liauw, Jason J. Ashworth, Nina Dempsey-Hibbert, Amina Belboul, Kathryn A. Whitehead

1372-1384
Downregulation of Sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease

Mahdieh Khanahmadi, Babak Manafi, Heidar Tayebinia, Jamshid Karimi, Iraj Khodadadi

1387-1398
Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption

Dietmar Enko, Sieglinde Zelzer, Julian Wenninger, Sandra Holasek, Wolfgang J. Schnedl, Andreas Baranyi, Markus Herrmann, Andreas Meinitzer

1414-1422
Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas

Roya Sajed, Leili Saeednejad Zanjani, Mandana Rahimi, Maryam Mansoori, Amir-Hassan Zarnani, Zahra Madjd, Roya Ghods

1423-1435
Revealing the astragalin mode of anticandidal action

Marija Ivanov, Abhilash Kannan, Dejan Stojkovic, Jasmina Glamočlija, Simona Golič Grdadolnik, Dominique Sanglard, Marina Soković

1436-1445
Overexpression of miRNA-145 induces apoptosis and prevents proliferation and migration of MKN-45 gastric cancer cells

Tahereh Zeinali, Leila Karimi, Nayer Hosseinahli, Dariush Shanehbandi, Behzad Mansoori, Ali Mohammadi, Khalil Hajiasgharzadeh, Zohreh Babaloo, Jafar Majidi-Zolbanin, Behzad Baradaran

1446-1458
Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells

B. Lucendo-Villarin, Patrick Nell, Birte Hellwig, P. Filis, David Feuerborn, P. J. O'Shaughnessy, Patricio Godoy, Jörg Rahnenführer, Jan G. Hengstler, A. Cherianidou, A. Sachinidis, P. A. Fowler, David C. Hay

1459-1476
Bio-impedance measurement allows displaying the early stages of neutrophil extracellular traps

Caren Linnemann, Sascha Venturelli, Franziska Konrad, Andreas K. Nussler, Sabrina Ehnert

1481-1495
iTRAQ-based proteomics reveals serum protein changes in hypertensive rats induced by a high-salt diet

Ying Qin, Tao Dong, Wan Jiang, Wen Ding, Tao Zhan, Juan Du, Ren Zhao, Bing Shen, Jiexia Chen

1496-1511
Circ_0010729 knockdown protects cardiomyocytes against hypoxic dysfunction via miR-370-3p/TRAF6 axis

Jingjing Zhang, Chuanyu Gao, Jing Zhang, Famin Ye

1520-1532
Clinical characteristics and outcomes of diabetics hospitalized for COVID-19 infection: a single-centered, retrospective, observational study

Asieh Mansour, Sayed Mahmoud Sajjadi-Jazi, Amir Kasaeian, Bardia Khosravi, Majid Sorouri, Fatemeh Azizi, Zeinab Rajabi, Fatemeh Motamedi, Azin Sirusbakht, Masoud Eslahi , Heila Mojtabbavi, Ali Reza Sima, Amir Reza Radmard, Mohhamad Reza Mohajeri-Tehrani, Mohammad Abdollahi

1533-1543

Review articles

Ovariectomized rat model of osteoporosis: a practical guide

Nasibeh Yousefzadeh, Khosrow Kashfi, Sajad Jeddi, Asghar Ghasemi

89-107
The survival rate of hepatocellular carcinoma in Asian countries: a systematic review and meta-analysis

Soheil Hassanipour, Mouhebat Vali, Saber Gaffari-fam, Hossein-Ali Nikbakht, Elham Abdzadeh, Farahnaz Joukar, Akram Pourshams, Afshin Shafaghi, Mahdi Malakoutikhah, Morteza Arab-Zozani, Hamid Salehiniya, Fariborz Mansour-Ghanaei

108-130
Serotonergic system modulation holds promise for L‐DOPA‐induced dyskinesias in hemiparkinsonian rats: A systematic review

Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Alireza Majdi, Fariba Pashazadeh, Seyyed Mehdi Vatandoust, Mojtaba Ziaee, Fatemeh Safari, Pouran Karimi, Javad Mahmoudi

268-295
Artificial sweeteners are related to non-alcoholic fatty liver disease: Microbiota dysbiosis as a novel potential mechanism

Hadi Emamat, Hamid Ghalandari, Hadith Tangestani, Afsoun Abdollahi, Azita Hekmatdoost

620-626
Prognostic role of immune cells in hepatocellular carcinoma

Meenakshi Sachdeva, Sunil K. Arora

718-733
3Rs toxicity testing and disease modeling projects in the European Horizon 2020 research and innovation program

Mathieu Vinken

775-784
Anaplastic thyroid cancer: How far can we go?

Mariana Amaral, Ricardo A. Afonso, Maria Manuela Gaspar, Catarina Pinto Reis

800-812
Pathophysiology and therapy of systemic vasculitides

Massimo Ralli, Flaminia Campo, Diletta Angeletti, Antonio Minni, Marco Artico, Antonio Greco, Antonella Polimeni, Marco de Vincentiis

817-854
Sulforaphane treatment for autism spectrum disorder: A systematic review

Greer McGuinness, Yeonsoo Kim

892-903
Inorganic nitrate, a natural anti-obesity agent: A systematic review and meta-analysis of animal studies

Zahra Bahadoran, Sajad Jeddi, Sevda Gheibi, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi

972-983
Current coronavirus (SARS-CoV-2) epidemiological, diagnostic and therapeutic approaches: An updated review until June 2020

Ahmed Nabil, Koichiro Uto, Mohamed M. Elshemy, Reham Soliman, Ayman A. Hassan, Mitsuhiro Ebara, Gamal Shiha

992-1016
Osteoporosis: Pathophysiology and therapeutic options

Ursula Föger-Samwald, Peter Dovjak, Ursula Azizi-Semrad, Katharina Kerschan-Schindl, Peter Pietschmann

1017-1037
State-dependent memory and its modulation by different brain areas and neurotransmitters

Mohammad-Reza Zarrindast, Fatemeh Khakpai

1081-1099
Biomaterials based on noncovalent interactions of small molecules

Jiaqi Guo, Changhao Tian, Bing Xu

1124-1140
Insulin secretion: The nitric oxide controversy

Sevda Gheibi, Asghar Ghasemi

1227-1245
A review on biogenic synthesis, applications and toxicity aspects of zinc oxide nanoparticles

Rajat Sharma, Rajni Garg, Avnesh Kumari

1325-1340
Interplay between reactive oxygen species and autophagy in the course of age-related macular degeneration

Małgorzata Nita, Andrzej Grzybowski

1353-1371
Why we do what we do. A brief analysis of cancer therapies

Carlos Maria Galmarini

1401-1413
Artificial Intelligence and its future potential in lung cancer screening

Christopher Joy Mathew, Ashwini Maria David, Chris Mariya Joy Mathew

1552-1562
Immunology of IL-12: An update on functional activities and implications for disease

Karen Anne-Marie Ullrich, Lisa Lou Schulze, Eva-Maria Paap, Tanja Martina Müller, Markus F. Neurath, Sebastian Zundler

1563-1589
Potential role of exosome in post-stroke reorganization and/or neurodegeneration

Fateme Azizi, Sahar Askari, Pegah Javadpour, Mahmoudreza Hadjighassem, Rasoul Ghasemi

1590-1606

Case reports

Mental disorder or conscious disturbance in epidermal growth factor receptor-tyrosine kinase inhibitor treatment of advanced lung adenocarcinoma

Jing Zhu, Rui Zhou, Heng Xiao

230-238
The effects of spaced transcranial Direct Current Stimulation combined with conventional dysphagia therapy in Parkinson’s disease: A case report

Ali Akbar Dashtelei, Michael A. Nitsche, Jalal Bakhtiyari, Seyed Amirhassan Habibi, Mojtaba Sepandi, Ahmad Reza Khatoonabadi

745-749
Undifferentiated pleomorphic sarcoma in the anterior mediastinum with a rapidly progressive course: A case report

Masamichi Sato, Sumito Inoue, Tsuyoshi Arao, Akira Igarashi, Keiko Yamauchi, Kento Sato, Hiroshi Nakano, Masafumi Watanabe

1161-1165
Severe rhabdomyolysis in homozygote carnitine palmitoyltransferase II deficiency

Wolfgang J. Schnedl, Michael Schenk, Dietmar Enko, Harald Mangge

1309-1313

Letters to the editor

Concurrent chronic myeloid leukemia and CALR-mutated myeloproliferative neoplasm

Stephen E. Langabeer

86-88
A recent overview on sulforaphane as a dietary epigenetic modulator

Tae Kyung Hyun

131-134
Highlight Report: Hepatobiliary differentiation from human induced pluripotent stem cells

Patrick Nell

167-169
Concomitant inflammation/metabolism transcriptional regulatory networks in liver disease

Tahany Abbas, Walaa Murad, Reham Hassan

183-184
The in vivo genotoxicity of isotretinoin assessed by comet assay

Maede Bordbar, Zahra Zendeh-Boodi, Mostafa Saadat

185-186
PPARG as therapeutic target for antifibrotic therapy

Ahmed Ghallab, Abdellatief Seddek

227-229
In-utero exposure to opioid increases the risk of congenital heart defects

Kamleshun Ramphul, Stephanie G. Mejias, Jyotsnav Joynauth

239-240
Linac-based radiotherapy for epicondylitis humeri

Mahmoud Navaser, Hamed Ghaffari, Mehrnaz Mashoufi, Soheila Refahi

296-300
Activation of the ATX-LPA axis by carcinogenic chemicals: New leads to prevent pancreatic cancer?

Johan Högberg

490-491
siRNA could be a potential therapy for COVID-19

Sanhita Ghosh, Sayeed Mohammad Firdous, Anirban Nath

528-531
Recent studies on kaempferol and its biological and pharmacological activities

Jae Kwang Kim, Sang Un Park

627-634
Current biological and pharmacological updates on wogonin

Sarita Rawat, Gaurav Gupta, Sachchidanand Pathak, Santosh Kumar Singh, Himmat Singh, Anurag Mishra, Ritu Gilhotra, Alaa A. A. Aljabali, Harish Dureja, Murtaza M. Tambuwala, Dinesh K. Chellappan, Kamal Dua

635-640
Genotoxicity effect of methyl-tertiary butyl ether on rat lymphocytes using comet assay

Shima Alishahi, Zahra Zendeh-Boodi, Mostafa Saadat

668-670
Nut consumption and risk of diabetes mellitus in overweight/obese individuals

Omid Eslami, Farzad Shidfar

705-706
Can post-splenectomy thrombocytosis mask essential thrombocythaemia?

Stephen E. Langabeer

773-774
COVID-19: Critical discussion on the applications and implications of chemicals in sanitizers and disinfectants

Olubunmi Atolani, Mariam Temitope Baker, Oluyomi Stephen Adeyemi, Ismaeel Ridwan Olanrewaju, Abdulmumeen A. Hamid, Oluduowo M. Ameen, Stephen O. Oguntoye, Lamidi A. Usman

785-799
The multifactorial resistance of Pseudomonas aeruginosa

Amina Meliani

813-816
Long time blood-transfusion trend in a European general hospital

Dietmar Enko, Markus Herrmann, Andreas Baranyi, Wolfgang J. Schnedl, Gabriele Halwachs-Baumann

855-860
Recent insights into the biological functions of apigenin

Jae Kwang Kim, Sang Un Park

984-991
Hepatotoxicity of anesthetic gases

Wiebke Albrecht

1052-1053
The link between long-term nut consumption and health outcomes: A hard nut to crack?

Omid Eslami, Farzad Shidfar

1100-1101
Recent pharmacological advances on genistein in clinical trials

Shimy Mathew, Cijo George Vazhappilly

1120-1123
Anticancer activity of luteolin glycosides

Ahmed Ghallab

1154-1155
Kupffer cells in hepatotoxicity

Reham Hassan

1156-1157
Do artificial sweeteners increase the risk of non-alcoholic fatty liver disease (NAFLD)?

Tahany Abbas, Walaa Murad

1158-1160
Vitamin D supplementation in COVID-19: A friend or foe?

Asieh Mansour, Mohammad Reza Mohajeri-Tehrani, Sayed Mahmoud Sajjadi-Jazi

1166-1168
Rethinking “Exercise is Medicine”

Shunchang Li, Ismail Laher

1169-1171
Which concentrations are optimal for in vitro testing?

Wiebke Albrecht

1172-1173
Reproductive toxicity of boron

Florian Seidel

1184-1185
Mitigation of metabolic dyshomeostasis by glucocorticoid-receptor antagonism: Insights from animal and human studies

Aishwariya Madhavan, Kusuma Murali, Vaishnavi Raghavendra, Apurva Kumar Ramesh Joshi

1266-1274
Immune responses during neoadjuvant chemotherapy in triple negative breast cancer

Ahmed Ghallab

1295-1296
Tea, coffee and risk of glioma

Tomoyuki Kawada

1314-1315
Brazil’s research budget: endless setbacks

Lucindo José Quintans-Júnior, George Rego Albuquerque, Sérgio Campello Oliveira, Robério Rodrigues Silva

1322-1324
Tea and coffee consumption, cognitive impairment and prognosis in older inhabitants

Tomoyuki Kawada

1385-1386
CALR mutations in myeloproliferative neoplasms: An unfolding story

Stephen E. Langabeer

1399-1400
Interferon therapy for preventing COPD exacerbations

Meenu Mehta, Keshav R. Paudel, Shakti D. Shukla, Madhur Shastri, Sachin K. Singh, Monica Gulati, Harish Dureja, Gaurav Gupta, Saurabh Satija, Philip M. Hansbro, Dinesh K. Chellappan, Kamal Dua

1477-1480
Emerging prospects of vitamin D3 in metabolic syndrome: A proof of concept (POC) approach targeting inflammation

Yogendra Singh , Gaurav Gupta, Ritu M. Gilhotra, Sachin Kumar Singh, Parteek Prasher, Anand Krishnan , Kamal Dua, Dinesh Kumar Chellappan

1512-1516
Ivermectin: Panacea or true promise for COVID-19

Luana Heimfarth, Victor Santana Santos, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Paulo Ricardo Martins-Filho

1517-1519
What about incorporating selenium in the therapeutic regimen of SARS-CoV-2?

Bachir Benarba, Atanasio Pandiella

1544-1546
Efficacy of tranexamic acid in patients with traumatic brain injury

Tomoyuki Kawada

1547-1548
Microbial determinants of arthritis

Shakti D. Shukla, Madhur D. Shastri, Niraj Kumar Jha, Kamal Dua

1549-1551
Examination of predictable factors of perioperative respiratory complications by preoperative forced oscillation technique parameters

Akira Igarashi, Sumito Inoue, Yoko Shibata, Keiko Nunomiya, Takahito Ota, Yu Ishibashi, Hiroaki Murano, Kodai Furuyama, Sujeong Yang, Hiroyoshi Machida, Hiroshi Nakano, Kento Sato, Masamichi Sato, Takako Nemoto, Michiko Nishiwaki, Keiko Yamauchi, Jun Suzuki, Mitsuaki Sadahiro, Masafumi Watanabe

1610-1614

Editorial material

Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated

Ahmed Ezzat Ahmed

1208-1210
Editor’s choice 2019: Oxidative stress and antineoplastic agents

Ahmed Ghallab

1607-1609
Editor’s choice 2018: Non-coding RNAs in hepatocellular cancer

Ahmed Ghallab

1615-1616