Serotonergic system modulation holds promise for L‐DOPA‐induced dyskinesias in hemiparkinsonian rats: A systematic review

Authors

  • Fereshteh Farajdokht Research Center for Evidence-Based Medicine (EBM), Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
  • Saeed Sadigh-Eteghad Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
  • Alireza Majdi Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
  • Fariba Pashazadeh Research Center for Evidence-Based Medicine (EBM), Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Iranian Evidence-Based Medicine (EBM) Center, a Joanna Briggs Institute Affiliated Group
  • Seyyed Mehdi Vatandoust Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
  • Mojtaba Ziaee Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Phytopharmacology Research Center, Maragheh University of Medical Sciences, Maragheh, Iran
  • Fatemeh Safari Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  • Pouran Karimi Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
  • Javad Mahmoudi Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran; Postal code: 5166614756, Iran, Tel: +984133351284, E-mails: mahmoudi2044@yahoo.com, mahmoudij@tbzmed.ac.ir

DOI:

https://doi.org/10.17179/excli2020-1024

Keywords:

L-DOPA, levodopa-induced dyskinesias, 6-hydroxydopamine, rat, serotonergic system

Abstract

The alleged effects of serotonergic agents in alleviating levodopa-induced dyskinesias (LIDs) in parkinsonian patients are debatable. To this end, we systematically reviewed the serotonergic agents used for the treatment of LIDs in a 6-hydroxydopamine model of Parkinson’s disease in rats. We searched MEDLINE via PubMed, Embase, Google Scholar, and Proquest for entries no later than March 2018, and restricted the search to publications on serotonergic agents used for the treatment of LIDs in hemiparkinsonian rats. The initial search yielded 447 citations, of which 49 articles and one conference paper met our inclusion criteria. The results revealed ten different categories of serotonergic agents, including but not limited to 5-HT1A/BR agonists, 5-HT2AR antagonists, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitor (SNRIs), and tricyclic antidepressants (TCAs), all of which improved LIDs without imposing considerable adverse effects. Although there is promising evidence regarding the role of these agents in relieving LIDs in hemiparkinsonian rats, further studies are needed for the enlightenment of hidden aspect of these molecules in terms of mechanisms and outcomes. Given this, improving the quality of the pre-clinical studies and designing appropriate clinical trials will help fill the bench-to-bedside gap.

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Published

2020-03-02

How to Cite

Farajdokht, F., Sadigh-Eteghad, S., Majdi, A., Pashazadeh, F., Vatandoust, S. M., Ziaee, M., … Mahmoudi, J. (2020). Serotonergic system modulation holds promise for L‐DOPA‐induced dyskinesias in hemiparkinsonian rats: A systematic review. EXCLI Journal, 19, 268–295. https://doi.org/10.17179/excli2020-1024

Issue

Vol. 19 (2020)

Section

Review articles

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