The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema

Authors

  • Saeideh Vafa Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • Shahpar Haghighat Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran. Tel: +982122890030. E-mail: sha_haghighat@yahoo.com
  • Leila Janani Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • Ali Saneei Totmaj Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • Mehraban Navaei Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • Ali Amirinejad Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • Hadi Emamat Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Zahra Salehi Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Mitra Zarrati Faculty of Nutrition, School of Public, Iran University of Medical Sciences, Tehran, Iran. Tel: +982186704814, Fax: +982186704814, E-mail: Zarrati_ms@yahoo.com, zarrati.m@iums.ac.ir

DOI:

https://doi.org/10.17179/excli2019-1876

Keywords:

inflammation, breast cancer, lymphedema, probiotic, prebiotic, caloric restriction

Abstract

Breast cancer-related lymphedema (BCRL) is one of the most common complications of breast cancer treatments, which may be exacerbated by obesity. Dysbiosis may negatively impact the management of obesity and lymphedema by increasing inflammation. The objective of this study was to assess the effects of supplementation with synbiotics on inflammatory markers, serum leptin concentration and edema volume in overweight and obese BCRL women following a low-calorie diet (LCD). In a randomized double-blind controlled clinical trial, 88 breast cancer survivors with lymphedema were supplemented once a day for 10 weeks with either a synbiotic or a placebo capsule. Both groups were under a low-calorie diet (LCD). At the end of the study, synbiotic supplementation resulted in a significant reduction in leptin (P=0.003) and TNF-α (P=0.039) between the study groups. Besides, edema volume was significantly reduced within the synbiotic group after the intervention. We did not observe any significant effects of the synbiotic supplementation in hs-CRP, and IL-1β between the study groups (P=0.550, P=0.118 respectively). Conclusively, synbiotic supplementation along with an LCD program in breast cancer survivors with lymphedema had beneficial effects on the concentration of serum inflammatory markers and edema volume.

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Published

2020-01-02

How to Cite

Vafa, S., Haghighat, S., Janani, L., Totmaj, A. S., Navaei, M., Amirinejad, A., … Zarrati, M. (2020). The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema. EXCLI Journal, 19, 1–15. https://doi.org/10.17179/excli2019-1876

Issue

Vol. 19 (2020)

Section

Original articles

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