Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway

Authors

  • Faiz Ahmad Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, India
  • Amit Sarder Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, India
  • Rajesh Gour Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, S.A.S Nagar, Punjab-160062, India
  • Shibendra Kumar Lal Karna Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, India
  • Priya Arora Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, India
  • P. Ravindranathan Kartha Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, S.A.S Nagar, Punjab-160062, India
  • Yuba Raj Pokharel Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, India, E-mail: yrp@sau.ac.in

DOI:

https://doi.org/10.17179/excli2020-1331

Keywords:

anhydrodihydroartemisinin, PC-3, apoptosis, caspase 3, caspase 7, c-Jun, Akt, NF-κB

Abstract

Cancer is a generic term for a large group of diseases characterized by the growth of abnormal cells, which is the second leading cause of death globally. To treat cancer, currently, a number of anticancer drugs belonging to various classes chemically are available. The discovery of artemisinin and its derivatives such as artesunate, arteether, and artemether became a milestone in the cure for malaria. Here, we report the anti-cancer property of anhydrodihydroartemisinin (ADHA) - a semisynthetic derivative of artemisinin against prostate cancer cell line PC-3. ADHA was found to be inhibiting growth of PC-3 cells. ADHA was also found to be inhibiting migration of PC-3 cells. At molecular level, ADHA was found to be inhibiting the expression of c-Jun, p-c-Jun, p-Akt and NF-κB and activated caspase 3 and 7. The results show that ADHA like few other artemisinin derivatives hold potential to be used as an anti-cancer agent against prostate cancer cells.

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Published

2020-05-11

How to Cite

Ahmad, F., Sarder, A., Gour, R., Karna, S. K. L., Arora, P., Kartha, P. R., & Pokharel, Y. R. (2020). Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway. EXCLI Journal, 19, 613–619. https://doi.org/10.17179/excli2020-1331

Issue

Vol. 19 (2020)

Section

Original articles

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