Potential role of exosome in post-stroke reorganization and/or neurodegeneration

Authors

  • Fateme Azizi Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Sahar Askari Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Pegah Javadpour Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mahmoudreza Hadjighassem Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. E-mail: mahmoudreza@hotmail.com
  • Rasoul Ghasemi Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Chamran highway, Velenjak, Tehran, Iran, Phone: + 98 21 22439971, E-mail: Rghasemi60@sbmu.ac.ir; r_ghasemi60@yahoo.com

DOI:

https://doi.org/10.17179/excli2020-3025

Keywords:

Stroke, Neurodegenerative Diseases, Exosome, miR9, miR124

Abstract

Currently, stroke is a common and devastating condition, which is sometimes associated with permanent cerebral damages. Although in early time after stroke, the related treatments are mainly focused on the restoration of cerebral blood flow (CBF), at the same time, some changes are commencing that continue for a long time and need to be specially noticed. Previous studies have proposed several molecular mechanisms in these post-stroke events. Exosomes are a type of vesicle, which are formed and secreted by most cells as a mean to transfer cellular constituents such as proteins, DNA and/or RNA to distant cells. Therefore, they are considered as a novel mechanism of cellular communication. Herein, we reviewed the current knowledge on cascades, which are activated after stroke and consequently lead to the reorganization and/or continuance of tissue damage and development of other disorders such as Neurodegenerative diseases (ND). Thereafter, we summarized the latest proofs about the possible participation of exosomes in transferring some components such as proteins and micro-RNAs (miRs), from the affected areas to other parts of the brain and eventually cause the above-mentioned post-stroke events. 

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Published

2020-12-11

How to Cite

Azizi, F. ., Askari, S. ., Javadpour, P. ., Hadjighassem, M. ., & Ghasemi, R. (2020). Potential role of exosome in post-stroke reorganization and/or neurodegeneration. EXCLI Journal, 19, 1590–1606. https://doi.org/10.17179/excli2020-3025

Issue

Vol. 19 (2020)

Section

Review articles

License

Copyright (c) 2020 Fateme Azizi, Sahar Askari, Pegah Javadpour, Mahmoudreza Hadjighassem, Rasoul Ghasemi

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