Sensitivity of clinical isolates of Candida to essential oils from Burseraceae family

Authors

  • Miloš Nikolic Institute for Biological Research "Siniša Stankovic", University of Belgrade, Bulevar Despota Stefana 142, 11000, Belgrade, Serbia
  • Marija Smiljkovic Institute for Biological Research "Siniša Stankovic", University of Belgrade, Bulevar Despota Stefana 142, 11000, Belgrade, Serbia
  • Tatjana Markovic Institute for Medicinal Plant Research "Josif Pancic", Tadeuša Košcuška 2, 11000 Belgrade, Serbia
  • Ana Cirica Institute for Biological Research "Siniša Stankovic", University of Belgrade, Bulevar Despota Stefana 142, 11000, Belgrade, Serbia
  • Jasmina Glamoclija Institute for Biological Research "Siniša Stankovic", University of Belgrade, Bulevar Despota Stefana 142, 11000, Belgrade, Serbia
  • Dejan Markovic Faculty of Dental Medicine, Department of Pediatric and Preventive Dentistry, University of Belgrade, dr Subotica 8, 11000 Belgrade, Serbia
  • Marina Sokovic Institute for Biological Research "Siniša Stankovic", University of Belgrade, Bulevar Despota Stefana 142, 11000, Belgrade, Serbia

DOI:

https://doi.org/10.17179/excli2014-621

Keywords:

Candida spp., susceptibility, essential oils, Burseraceae, oral candidosis

Abstract

The aim of this study was to investigate the chemical composition and antifungal activity of four commercial essential oils from the Burseraceae family - two Boswellia carterii Flueck oils, Canarium luzonicum (Blume) A. Gray oil, and Commiphora myrrha (Nees) Engl oil, against most common Candida spp. recovered from the human oral cavity. The essential oil samples were analyzed by GC-FID and GC/MS. The analysis showed that major essential oils' components were α-pinene (23.04 % and 31.84 %), limonene (45.62 %) and curzerene (34.65 %), respectively. Minimum inhibitory (MIC) and minimum fungicidal (MFC) concentrations were determined using a microdilution standardized technique. All tested Candida spp. clinical isolates and ATCC strains showed susceptibility to tested essential oils in a dose dependent manner. The strongest antifungal activity was shown by essential oil of B. carterii, sample 2; the average MIC values ranged from 1.25 to 1.34 mg/ml, and MFC values ranged from 2.50 to 3.75 mg/ml, depending on the fungus. This study supports the possible use of essential oils from the Bursecaceae family in reduction and elimination of Candida spp. populations in patients with oral cavity fungal infections.

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Published

2016-04-19

How to Cite

Nikolic, M., Smiljkovic, M., Markovic, T., Cirica, A., Glamoclija, J., Markovic, D., & Sokovic, M. (2016). Sensitivity of clinical isolates of Candida to essential oils from Burseraceae family. EXCLI Journal, 15, 280–289. https://doi.org/10.17179/excli2014-621

Issue

Vol. 15 (2016)

Section

Original articles

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