Differential pattern of brain functional connectome in obsessive-compulsive disorder versus healthy controls

Authors

  • Saeid Yazdi-Ravandi Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  • Hassan Akhavanpour Institute for Cognitive and Brain Sciences, Shahid Beheshti University GC, Tehran, Iran
  • Farshid Shamsaei Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  • Nasrin Matinnia Department of Nursing, College of Basic Science, Hamadan Branch, Islamic Azad University, Hamadan, Iran
  • Mohammad Ahmadpanah Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  • Ali Ghaleiha Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  • Reza Khosrowabadi Institute for Cognitive and Brain Sciences, Shahid Beheshti University GC, Tehran, Iran

DOI:

https://doi.org/10.17179/excli2018-1757

Keywords:

electroencephalography (EEG), obsessive-compulsive disorder (OCD), functional connectivity (FC), weighted phase lag index (WPLI)

Abstract

Researchers believe that recognition of functional impairment in some of brain networks such as frontal-parietal, default mode network (DMN), anterior medial prefrontal cortex (MPFC) and striatal structures could be a beneficial biomarker for diagnosis of obsessive-compulsive disorder (OCD). Although it is well recognized brain functional connectome in OCD patients shows changes, debate still remains on characteristics of the changes. In this regard, little has been done so far to statistically assess the altered pattern using whole brain electroencephalography. In this study, resting state EEG data of 39 outpatients with OCD and 19 healthy controls (HC) were recorded. After, brain functional network was estimated from the cleaned EEG data using the weighted phase lag index algorithm. Output matrices of OCD group and HCs were then statistically compared to represent meaningful differences. Significant differences in functional connectivity pattern were demonstrated in several regions. As expected the most significant changes were observed in frontal cortex, more significant in frontal-temporal connections (between F3 and F7, and T5 regions). These results in OCD patients are consistent with previous studies and confirm the role of frontal and temporal brain regions in OCD.

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Published

2018-11-08

How to Cite

Yazdi-Ravandi, S., Akhavanpour, H., Shamsaei, F., Matinnia, N., Ahmadpanah, M., Ghaleiha, A., & Khosrowabadi, R. (2018). Differential pattern of brain functional connectome in obsessive-compulsive disorder versus healthy controls. EXCLI Journal, 17, 1090–1100. https://doi.org/10.17179/excli2018-1757

Issue

Vol. 17 (2018)

Section

Original articles

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