Association between the CD40 rs1883832 polymorphism and Graves' disease risk: a meta-analysis

Authors

  • Xiao-Xiong Wang Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Beijing, China
  • Xiao-Xia Wang Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China
  • Tong Chen Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, No.1 DaHua Road, Dong Dan, Beijing, 100730, China; Tel: +86-10-85133370; E-mail: chentong7303@sina.com

DOI:

https://doi.org/10.17179/excli2017-916

Keywords:

CD40, Graves’ disease, meta-analysisp, polymorphism

Abstract

This meta-analysis aims to evaluate whether the CD40 rs1883832 polymorphism is associated with Graves’ disease (GD) risk in different populations. We performed a systematic literature search in China National Knowledge Infrastructure (CNKI), Web of Science, and Pubmed databases to identify case-control association studies on the association between rs1883832 and GD risk. For each study we calculated the odds ratios (OR) and 95 % confidence intervals (CI) assuming dominant, recessive and homozygote models. We then calculated pooled ORs and 95 % CIs. After applying inclusion and exclusion criteria, 17 studies involving 4707 cases and 4215 controls were included in the meta-analysis. The results showed that rs1883832 was associated with GD risk in Asians under dominant (CT + TT vs CC, OR=0.67, 95 % CI: 0.56-0.81, P<0.001), recessive (TT vs CT + CC, OR=0.58, 95 % CI: 0.47-0.72, P<0.001), and homozygote (TT vs CC, OR=0.49, 95 % CI: 0.37-0.64, P<0.001) models. In Caucasians, rs1883832 was associated with GD risk under the dominant model (CT + TT vs CC, OR=0.82, 95 % CI: 0.68-0.99, P=0.042). Besides GD, we evaluated the relation of rs1883832 with Graves’ ophthalmopathy (GO), finding that rs1883832 was associated with GO under the dominant model (CT + TT vs CC, OR=0.82, 95 % CI: 0.69-0.98, P=0.031). The findings of our meta-analysis suggest that the CD40 rs1883832 polymorphism is protective against GD and GO in Asians and Caucasians.

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Published

2019-01-23

How to Cite

Wang, X.-X., Wang, X.-X., & Chen, T. (2019). Association between the CD40 rs1883832 polymorphism and Graves’ disease risk: a meta-analysis. EXCLI Journal, 18, 10–20. https://doi.org/10.17179/excli2017-916

Issue

Vol. 18 (2019)

Section

Original articles

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