Advances in cartilage tissue regeneration

a review of stem cell therapies, tissue engineering, biomaterials, and clinical trials

Authors

  • Julia Skoracka Poznan University of Medical Sciences, Poznan, Poland, Fredry 10 Street, 61-701 Poznań, Poland https://orcid.org/0009-0008-0560-7617
  • Kaja Bajewska Poznan University of Medical Sciences, Poznan, Poland, Fredry 10 Street, 61-701 Poznań, Poland https://orcid.org/0009-0009-4920-7372
  • Maciej Kulawik Poznan University of Medical Sciences, Poznan, Poland, Fredry 10 Street, 61-701 Poznań, Poland https://orcid.org/0009-0007-1522-556X
  • Wiktoria M. Suchorska Department of Electroradiology, Poznan University of Medical Sciences, Garbary 15 Street, 61-866 Poznan, Poland; Radiobiology Laboratory, Greater Poland Cancer Centre, Garbary 15 Street, 61-866 Poznan, Poland https://orcid.org/0000-0003-4742-2465
  • Katarzyna Kulcenty Radiobiology Laboratory, Greater Poland Cancer Centre, Garbary 15 Street, 61-866 Poznan, Poland. Tel. +4861 8850 476; E-mail: katarzyna.kulcenty@wco.pl https://orcid.org/0000-0001-8400-249X

DOI:

https://doi.org/10.17179/excli2024-7088

Keywords:

cartilage regeneration, stem cells, tissue engineering, biomaterials, 3D bioprinting, clinical trials, organ-on-chip

Abstract

Cartilage tissue, characterized by its limited regenerative capacity, presents significant challenges in clinical therapy. Recent advancements in cartilage regeneration have focused on integrating stem cell therapies, tissue engineering strategies, and advanced modeling techniques to overcome existing limitations. Stem cells, particularly Mesenchymal Stem Cells (MSCs) and induced pluripotent stem cells (iPSCs), hold promise for cartilage repair due to their ability to differentiate into chondrocytes, the key cells responsible for cartilage formation. Tissue engineering approaches, including 3D models, organ-on-a-chip systems, and organoids, offer innovative methods to mimic natural tissue microenvironments and evaluate potential treatments. MSC-based techniques, such as cell sheet tissue engineering, address challenges associated with traditional therapies, including cell availability and culture difficulties. Furthermore, advancements in 3D bioprinting enable the fabrication of complex tissue structures, while organ-on-a-chip systems provide microfluidic platforms for disease modeling and physiological mimicry. Organoids serve as simplified models of organs, capturing some complexity and enabling the monitoring of pathophysiological aspects of cartilage diseases. This comprehensive review underscores the transformative potential of integrating stem cell therapies, tissue engineering strategies, and advanced modeling techniques to improve cartilage regeneration and pave the way for more effective clinical treatments.

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Published

2024-09-03

How to Cite

Skoracka, J., Bajewska, K., Kulawik, M., Suchorska, W. M., & Kulcenty, K. (2024). Advances in cartilage tissue regeneration: a review of stem cell therapies, tissue engineering, biomaterials, and clinical trials. EXCLI Journal, 23, 1170–1182. https://doi.org/10.17179/excli2024-7088

Issue

Vol. 23 (2024)

Section

Review articles

Categories

License

Copyright (c) 2024 Julia Skoracka, Kaja Bajewska, Maciej Kulawik, Wiktoria M. Suchorska, Katarzyna Kulcenty

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