Anti-atherogenic potential of jujube, saffron and barberry: anti-diabetic and antioxidant actions

Authors

  • Mina Hemmati Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran; Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  • Elham Zohoori Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  • Omid Mehrpour Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran
  • Mehdi Karamian Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
  • Somaye Asghari Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  • Asghar Zarban Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  • Roya Nasouti Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran

DOI:

https://doi.org/10.17179/excli2015-232

Keywords:

Atherogenic dyslipidemia, adiponectin, antioxidant, diabetes, medicinal plants

Abstract

Atherogenic dyslipidemia, characterized by an increased level of lipoprotein (a) and a decreased level of adiponectin, is a major risk factor for cardiovascular diseases in diabetic patients. To reduce cardiovascular risk in diabetic patients, use of agents with antidiabetic and anti-atherogenic potential is required. Using an animal model of diabetes, we investigated the antiatherogenic potential of extracts of three medicinal plants: jujube, barberry, and saffron. For this, serum level of fasting blood glucose, lipid profile, malondialdehyde, total antioxidant capacity, adiponectin and lipoprotein (a) in diabetic control and extract treated groups were measured. Statistical analysis of measurements showed that serum levels of fasting blood glucose, triglyceride, and VLDL decreased significantly (P < 0.05) in all treated groups. Treatment with all extracts reduced lipid peroxidation and increased antioxidant capacity of the experimental diabetic groups. Serum adiponectin levels increased in all treated groups, whereas lipoprotein (a) levels decreased, most markedly when treated with jujube extract. Jujube, saffron, and barberry extracts are beneficial in ameliorating oxidative stress and atherogenic risk of diabetic rats. This highlights the benefits of further investigating the cardio-protective potential of medicinal plant extracts and evaluating their usefulness as cardio protective agents in clinical practice.

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Published

2015-08-04

How to Cite

Hemmati, M., Zohoori, E., Mehrpour, O., Karamian, M., Asghari, S., Zarban, A., & Nasouti, R. (2015). Anti-atherogenic potential of jujube, saffron and barberry: anti-diabetic and antioxidant actions. EXCLI Journal, 14, 908–915. https://doi.org/10.17179/excli2015-232

Issue

Vol. 14 (2015)

Section

Original articles

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