The effect of hydroalcoholic extract of Achillea eriophora DC. on blood pressure of anaesthetized male rat

Authors

  • Sohrab Anvari Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
  • Aminollah Bahaoddini Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
  • Mahmoodreza Moein Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  • Ahmad Reza Khosravi Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran

DOI:

https://doi.org/10.17179/excli2016-529

Keywords:

Achillea eriophora, hypotension, cholinergic system, nitrergic system

Abstract

Achillea eriophora (Asteraceae) is a medicinal plant commonly used in Iran. This study was performed to determine the cardiovascular effects of hydroethanolic extract of A. eriophora (HEAE) and the underlying mechanisms in anaesthetized rats. The acute effects of intravenous (i.v.) administration of different doses of HEAE (40, 50, 60, 80 mg/kg), and its probable interaction with cholinergic and nitrergic systems were investigated in the presence of ACh and NOS blocker (L-NAME) as well as ethanol (HEAE solvent in sham group). Intravenous administration of different doses of HEAE induced hypotension. HEAE (60 mg/kg) significantly reduced mean arterial blood pressure (MAP), systolic arterial blood pressure (SBP) and diastolic arterial blood pressure (DBP) compared to control rats that treated with ethanol only, but no change in heart rate (HR) was seen in both groups. The results showed significant decrease in MAP, SBP, DBP and increase of HR in the presence of HEAE plus ACh (10 µg/kg) compared to when ACh was injected alone. Finally i.v. administration of HEAE, significantly reduced MAP and DBP in L-NAME (5 mg/kg) treated animals, while bradycardic responses to L-NAME were not significantly changed by HEAE. It can be concluded that Achillea eriophora induced hypotensive effect via lowering total peripheral resistance and cardiac output that may be synergist with cholinergic and independent of nitrergic system.

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Published

2016-12-07

How to Cite

Anvari, S., Bahaoddini, A., Moein, M., & Khosravi, A. R. (2016). The effect of hydroalcoholic extract of Achillea eriophora DC. on blood pressure of anaesthetized male rat. EXCLI Journal, 15, 797–806. https://doi.org/10.17179/excli2016-529

Issue

Vol. 15 (2016)

Section

Original articles

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