Lupane-type triterpenes and their anti-cancer activities against most common malignant tumors: A review

Authors

  • MH Cháirez-Ramírez Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México
  • MR Moreno-Jiménez Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México
  • RF González-Laredo Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México
  • JA Gallegos-Infante Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México
  • Nuria Elizabeth Rocha-Guzmán Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México

DOI:

https://doi.org/10.17179/excli2016-642

Keywords:

lupeol, betulin, betulinic acid, cancer, signaling pathway

Abstract

In recent times, a great deal of interest has been motivated on plant derived compounds known as nutraceuticals. These compounds exert important beneficial activities that improve people's health status when are consumed regularly, and now they appear as a viable option to explore their possible therapeutic effects against diseases like cancer. Particularly, lupane-type triterpenes have shown great ability to modulate multiple cancer-related signaling pathways and processes, including NF-κB, Wnt/β-catenin, PI3K/Akt, apoptosis, and many other routes related to proliferation or cell death, which are uncontrolled in malignant tumors. These investigations have promoted in vitro and in vivo studies, searching their mechanisms of action; although more research is still needed to prove its potential in human clinical trials. This review focuses on the ability of betulin, betulinic acid and lupeol to show benefits against the most common types of malignant tumors, which are considered a major global threat for public health.

Downloads

Published

2016-11-30

How to Cite

Cháirez-Ramírez, M., Moreno-Jiménez, M., González-Laredo, R., Gallegos-Infante, J., & Rocha-Guzmán, N. E. (2016). Lupane-type triterpenes and their anti-cancer activities against most common malignant tumors: A review. EXCLI Journal, 15, 758–771. https://doi.org/10.17179/excli2016-642

Issue

Vol. 15 (2016)

Section

Review articles

License

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).

Most read articles by the same author(s)