Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants

Authors

  • Asuman Özgöz Kastamonu Üniversitesi, Kuzeykent Kampüsü, Fazıl Boyner Sağlık Bilimleri Fakültesi, Kuzeykent Mah. Orgeneral Atilla Ateş Paşa Cd. No: 19 C, 37200 Kastamonu, Turkey. Tel.: +90 366 2804104; Fax: +90 366 215 28 89; E-mail: biologistasu@gmail.com https://orcid.org/0000-0003-4018-5807
  • Fadime Mutlu İçduygu School of Medicine, Department of Medical Genetics, Giresun University, Giresun, Turkey https://orcid.org/0000-0002-4913-9420
  • Ayşegül Yükseltürk Fazıl Boyner Faculty of Health Sciences, Department of Nutrition and Dietetics, Kastamonu University, Kastamonu, Turkey https://orcid.org/0000-0001-7550-0569
  • Hale Şamli School of Veterinary Medicine, Department of Genetics, Uludağ University, Bursa, Turkey https://orcid.org/0000-0003-4728-0735
  • Kuyaş Hekimler Öztürk School of Medicine, Department of Medical Genetics, Süleyman Demirel University, Isparta, Turkey https://orcid.org/0000-0002-7075-8875
  • Zuhal Başkan Department of Medical Oncology, Acıbadem Bursa Hospital, 16110 Bursa, Turkey https://orcid.org/0000-0002-1191-3599
  • İlknur Tütüncü † Fazıl Boyner Faculty of Health Sciences, Department of Nutrition and Dietetics, Kastamonu University, Kastamonu, Turkey

DOI:

https://doi.org/10.17179/excli2020-2860

Keywords:

ADIPOQ, FTO, polymorphism, postmenopausal, breast cancer

Abstract

Obesity is one of the most important health risks in postmenopausal women. Molecular pathways that are connected with obesity are believed to interact with the pathogenesis of breast cancer (BC). The aim of this research was to study the polymorphisms of two obesity-associated genes ADIPOQ and FTO that are also related to the pathogenesis of BC. Obesity-associated gene polymorphisms ADIPOQ rs1501299 and rs2241766, and FTO rs1477196, rs7206790, rs8047395, and rs9939609 were studied in 101 Turkish postmenopausal estrogen receptor-positive BC patients and 100 healthy control individuals. ADIPOQ rs1501299 was detected to be associated with protection against BC. The ADIPOQ rs1501299 TT genotype, the rs2241766 GT genotype and the G allele were found to be significantly higher in the control group. In addition, ADIPOQ rs1501299 polymorphism was protective in the recessive model and rs2241766 polymorphism was protective in the dominant model. While none of the FTO gene polymorphisms were found to be associated with BC, the frequencies of rs9939609 A allele and rs7206790 G allele were correlated with body mass index (BMI) in BC patients. ADIPOQ rs1501299 TT genotype, rs2241766 GT genotype, and G allele might be protective against BC in the Turkish population but this conclusion needs to be further verified.

Author Biography

Asuman Özgöz, Kastamonu Üniversitesi, Kuzeykent Kampüsü, Fazıl Boyner Sağlık Bilimleri Fakültesi, Kuzeykent Mah. Orgeneral Atilla Ateş Paşa Cd. No: 19 C, 37200 Kastamonu, Turkey. Tel.: +90 366 2804104; Fax: +90 366 215 28 89; E-mail: biologistasu@gmail.com

https://orcid.org/0000-0003-4018-5807

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Published

2021-07-05

How to Cite

Özgöz, A., Mutlu İçduygu, F., Yükseltürk, A., Şamli, H., Hekimler Öztürk, K., Başkan, Z., & Tütüncü †, İlknur. (2021). Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants. EXCLI Journal, 20, 1133–1144. https://doi.org/10.17179/excli2020-2860

Issue

Vol. 20 (2021)

Section

Original articles

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Copyright (c) 2021 Asuman Özgöz, Fadime Mutlu İçduygu, Ayşegül Yükseltürk, Hale Şamli, Kuyaş Hekimler Öztürk, Zuhal Başkan

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