Competing endogenous RNA networks in ovarian cancer

from bench to bedside

Authors

  • Roghaiyeh Derogar Fellowship in Gynecologic Oncology, Department of Gynecology, Faculty of Medical Sciences, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran https://orcid.org/0009-0009-8926-1138
  • Fatemeh Nejadi Orang Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran https://orcid.org/0009-0006-7381-0436
  • Mahdi Abdoli Shadbad Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Daneshgah St., Tabriz, Iran. Phone No: +(98) 9036433290, E-mail: abdoli.med99@gmail.com https://orcid.org/0000-0003-4865-8779

DOI:

https://doi.org/10.17179/excli2024-7827

Keywords:

ceRNA network, microRNAs (miRNAs), circular RNA, competing endogenous RNAs, long non-coding RNA, ovarian cancer

Abstract

Epithelial ovarian cancer is responsible for the majority of ovarian malignancies, and its highly invasive nature and chemoresistant development have been major obstacles to treating patients with mainstream treatments. In recent decades, the significance of microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and competing endogenous RNAs (ceRNAs) has been highlighted in ovarian cancer development. This hidden language between these RNAs has led to the discovery of enormous regulatory networks in ovarian cancer cells that substantially affect gene expression. Aside from providing ample opportunities for targeted therapies, circRNA- and lncRNA-mediated ceRNA network components provide invaluable biomarkers. The current study provides a comprehensive and up-to-date review of the recent findings on the significance of these ceRNA networks in the hallmarks of ovarian cancer oncogenesis, treatment, diagnosis, and prognosis. Also, it provides the authorship with future perspectives in the era of single-cell RNA sequencing and personalized medicine.

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Published

2025-01-07

How to Cite

Derogar, R., Nejadi Orang, F., & Abdoli Shadbad, M. (2025). Competing endogenous RNA networks in ovarian cancer: from bench to bedside. EXCLI Journal, 24, 86–112. https://doi.org/10.17179/excli2024-7827

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Section

Review articles

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