Smoking increases risk of complication after musculoskeletal surgery

analysis of single immune parameter to predict complication risk

Authors

  • Leyla Tümen Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany; Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, 72076 Tübingen, Germany https://orcid.org/0000-0001-7182-9404
  • Lena Pollmann-Schweckhorst Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany https://orcid.org/0009-0002-1796-3287
  • Regina Breinbauer Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany https://orcid.org/0009-0001-7172-9443
  • Mohammad M. Hammour Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany https://orcid.org/0009-0006-6679-2495
  • Romina H. Aspera-Werz Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany
  • Gunnar Blumenstock Department of Medical Biometry, Eberhard Karls University Tübingen, 72076 Tübingen, Germany https://orcid.org/0000-0002-0129-4827
  • Tina Histing Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, 72076 Tübingen, Germany
  • Maximilian M. Menger Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, 72076 Tübingen, Germany https://orcid.org/0000-0002-1261-9877
  • Sabrina Ehnert Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany https://orcid.org/0000-0003-4347-1702
  • Andreas Nüssler Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany. Phone: +49 7071 606 1065, Fax: +49 7071 606 1978, E-mail: Andreas.Nuessler@med.uni-tuebingen.de https://orcid.org/0000-0002-6666-6791

DOI:

https://doi.org/10.17179/excli2024-7306

Keywords:

smoking, systemic immune inflammation index, SII, complications, surgery, trauma

Abstract

Smoking is the most significant and modifiable risk factor for a range of conditions, including cancer, cardiovascular and respiratory diseases. Furthermore, it significantly reduces bone mass and increases the risk of fragility fractures due to its detrimental effects on bone metabolism and regeneration. Moreover, smoking is a known cause of chronic systemic inflammation, leading to an imbalance of cytokines. Comprehending the pathological mechanisms that underlie cytokine production and its impact on post-surgical healing is essential to prevent post-surgical complications. The present study recruited a total of 1144 patients, including 897 patients, among them non-smokers (N = 413), current smokers (N = 201) and ex-smokers (N = 283). Human proteome profiler arrays were used to screen for smoking-dependent differences in the serum cytokine and protein profiles, after matching samples for age, gender, body mass index (BMI), alcohol use, and diabetes risk. Cytokines and immune checkpoint proteins such as CD28, B7-1, MIG, TGFb2 and IL-1a/b were quantified by ELISA. Our study demonstrates a comprehensive understanding of the relationship between smoking, the development of complications, the systemic immune inflammation index (SII) and cytokine/protein levels. We found that a comparison of non-smokers, former smokers, and active smokers in our study cohort did not exhibit significantly altered cytokine and protein serum levels although other studies reported differences between smokers and non-smokers. We were unable to identify single blood circulating markers that could predict complications in smokers after trauma. However, we found the ratio of women to men to be inverted between non-smokers and active smokers resulting in a ratio of 0.62 in smokers. Furthermore, we demonstrate a higher complication rate, longer hospitalizations and elevated SII values among smokers, indicating an involvement of the immune system.

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Published

2024-07-13

How to Cite

Tümen, L., Pollmann-Schweckhorst, L., Breinbauer, R., Hammour, M. M., Aspera-Werz, R. H., Blumenstock, G., … Nüssler, A. (2024). Smoking increases risk of complication after musculoskeletal surgery: analysis of single immune parameter to predict complication risk. EXCLI Journal, 23, 967–990. https://doi.org/10.17179/excli2024-7306

Issue

Vol. 23 (2024)

Section

Original articles

Categories

License

Copyright (c) 2024 Leyla Tümen, Lena Pollmann-Schweckhorst, Regina Breinbauer, Mohammad M. Hammour, Romina H. Aspera-Werz, Gunnar Blumenstock, Tina Histing, Maximilian M. Menger, Sabrina Ehnert, Andreas Nüssler

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