Molecular targeted therapies for cutaneous squamous cell carcinoma

recent developments and clinical implications

Authors

  • Harpreet Singh School of Pharmaceutical Sciences, IFTM University, Moradabad, U.P., India, 244102; E-mail: harpreetproctor@rediffmail.com https://orcid.org/0000-0001-5229-6569
  • Hitesh Chopra Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai - 602105, Tamil Nadu, India https://orcid.org/0000-0002-1406-6903
  • Inderbir Singh Chitkara College of Pharmacy, Chitkara University, Punjab, India https://orcid.org/0000-0002-1860-4246
  • Sourav Mohanto Department of Pharmaceutics, Yenepoya Pharmacy College & Research Center, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, India https://orcid.org/0000-0001-5599-5445
  • Mohammed Gulzar Ahmed Department of Pharmaceutics, Yenepoya Pharmacy College & Research Center, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, India https://orcid.org/0000-0002-9226-9984
  • Shruti Ghumra Department of Biological Sciences, Sunandan Divatia School of Science, NarseeMonjee Institute of Management Studies (NMIMS), Pherozeshah Mehta Rd, Mumbai, India, 400056 https://orcid.org/0000-0002-1632-7193
  • Anmol Seelan Mahatma Gandhi Mission, Institute of Biosciences and Technology, Aurangabad, India https://orcid.org/0009-0008-2799-3328
  • Manisha Survase Mahatma Gandhi Mission, Institute of Biosciences and Technology, Aurangabad, India https://orcid.org/0000-0002-0006-3533
  • Arvind Kumar School of Pharmaceutical Sciences, IFTM University, Moradabad, U.P., India, 244102 https://orcid.org/0000-0003-4754-5318
  • Amrita Mishra School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India, 110017 https://orcid.org/0000-0003-4729-909X
  • Arun Kumar Mishra SOS School of Pharmacy, IFTM University, Moradabad, U.P., India, 244102 https://orcid.org/0000-0002-8569-988X
  • Mohammad Amjad Kamal Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, China; E-mail: rrs.usa.au@gmail.com https://orcid.org/0000-0003-0088-0565

DOI:

https://doi.org/10.17179/excli2023-6489

Keywords:

skin cancer, clinical trials, combination strategies, clinical implications, patient

Abstract

Cutaneous Squamous Cell Carcinoma (cSCC) is a common and potentially fatal type of skin cancer that poses a significant threat to public health and has a high prevalence rate. Exposure to ultraviolet radiation on the skin surface increases the risk of cSCC, especially in those with genetic syndromes like xerodermapigmentosum and epidermolysis bullosa. Therefore, understanding the molecular pathogenesis of cSCC is critical for developing personalized treatment approaches that are effective in cSCC. This article provides a comprehensive overview of current knowledge of cSCC pathogenesis, emphasizing dysregulated signaling pathways and the significance of molecular profiling. Several limitations and challenges associated with conventional therapies, however, are identified, stressing the need for novel therapeutic strategies. The article further discusses molecular targets and therapeutic approaches, i.e., epidermal growth factor receptor inhibitors, hedgehog pathway inhibitors, and PI3K/AKT/mTOR pathway inhibitors, as well as emerging molecular targets and therapeutic agents. The manuscript explores resistance mechanisms to molecularly targeted therapies and proposes methods to overcome them, including combination strategies, rational design, and optimization. The clinical implications and patient outcomes of molecular-targeted treatments are assessed, including response rates and survival outcomes. The management of adverse events and toxicities in molecular-targeted therapies is crucial and requires careful monitoring and control. The paper further discusses future directions for therapeutic advancement and research in this area, as well as the difficulties and constraints associated with conventional therapies.

Published

2024-02-27

How to Cite

Singh, H., Chopra, H., Singh, I., Mohanto, S., Ahmed, M. G., Ghumra, S., … Kamal, M. A. (2024). Molecular targeted therapies for cutaneous squamous cell carcinoma: recent developments and clinical implications. EXCLI Journal, 23, 300–334. https://doi.org/10.17179/excli2023-6489

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Review articles

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