lncRNA involvement in hepatocellular carcinoma metastasis and prognosis

Authors

  • Maryam Abbastabar Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran
  • Mohammad Sarfi Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran
  • Abolfazl Golestani Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran
  • Ehsan Khalili Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran

DOI:

https://doi.org/10.17179/excli2018-1541

Keywords:

hepatocellular carcinoma (HCC), long non-coding RNA (lncRNAs), metastasis, prognosis, liver

Abstract

Eukaryotic lncRNAs are RNA molecules defined to be greater than 200 bp in length that are not translated to a protein and operate through several mechanisms, including participating in chromatin remodeling and methylation, influencing the integrity and stability of proteins and complexes, or acting as a sponge for miRNA inhibition. A number of recent studies have concentrated on the relationship between long non-coding RNAs (lncRNAs) and cancer. Hepatocellular carcinoma (HCC) is the most prevalent histological type of liver tumors, accounting for about 80 % of the cases worldwide. Lack of proper molecular markers for diagnosis of HCC and treatment evaluation is a significant problem. Dysregulated expression of HCC-related lncRNAs such as MEG-3, MALAT1, HULC, HOTAIR, and H19 have been identified and closely related with tumorigenesis, metastasis, prognosis and diagnosis. In this review, we summarized recent highlighted functions and molecular mechanisms of the most extensively studied lncRNAs in the pathophysiology of hepatocellular carcinoma and their potential for serving as probable therapeutic targets.

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Published

2018-09-04

How to Cite

Abbastabar, M., Sarfi, M., Golestani, A., & Khalili, E. (2018). lncRNA involvement in hepatocellular carcinoma metastasis and prognosis. EXCLI Journal, 17, 900–913. https://doi.org/10.17179/excli2018-1541

Issue

Vol. 17 (2018)

Section

Review articles

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