Study on genotoxicity, oxidative stress biomarkers and clinical symptoms in workers of an asbestos-cement factory

Authors

  • Azam Afaghi Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Shahrbanoo Oryan Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Kobra Rahzani Arak University of Medical Science, Arak, Iran
  • Mohammad Abdollahi Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Science, Tehran, Iran

DOI:

https://doi.org/10.17179/excli2015-469

Keywords:

asbestos, plant, oxidative stress, DNA damage, malondialdehyde, total thiol molecule, total antioxidant capacity

Abstract

The purpose of the present study was to investigate whether the markers of oxidative stress could be altered in workers exposed to asbestos. A comparative cross-sectional research was conducted in a group of 50 subjects exposed to asbestos and another group of 50 with the same age and sex unexposed to asbestos. Malondialdehyde (MDA), total thiol molecule (TTM), total antioxidant capacity (TAC), and DNA damage, were measured in the blood samples of workers and controls. Compared to the control group, the workers showed higher blood levels of DNA damage (P=0.0001) and MDA (P=0.0001). The workers showed lower TTM (P=0.02) as compared with the control group. There was no considerable difference on the level of TAC (P=0.1) between the groups. The workers indicated clinical symptoms such as breathlessness, phlegm, coughing and wheezing. There was a positive correlation between levels of 8-OHdG and MDA of asbestos workers and the smoking status suggesting the negative role of smoking.

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Published

2015-09-28

How to Cite

Afaghi, A., Oryan, S., Rahzani, K., & Abdollahi, M. (2015). Study on genotoxicity, oxidative stress biomarkers and clinical symptoms in workers of an asbestos-cement factory. EXCLI Journal, 14, 1067–1077. https://doi.org/10.17179/excli2015-469

Issue

Vol. 14 (2015)

Section

Original articles

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