A glance at the actual role of glutamine metabolism in thyroid tumorigenesis

Authors

  • Raziyeh Abooshahab Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Curtin Medical School, Curtin University, Bentley 6102, Australia https://orcid.org/0000-0001-7379-0339
  • Kourosh Hooshmand Steno Diabetes Center Copenhagen, Gentofte, Denmark https://orcid.org/0000-0002-6970-5725
  • Fatemeh Razavi Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran https://orcid.org/0000-0001-6519-0341
  • Crispin R. Dass Curtin Medical School, Curtin University, Bentley 6102, Australia. Office: Curtin Health Innovation Research Institute, Bldg 305, Room 124, Curtin University, Bentley campus. Phone: +61 8 9266 1489, E-mail: Crispin.Dass@curtin.edu.au https://orcid.org/0000-0001-7087-7957
  • Mehdi Hedayati Cellular and Molecular Endocrine Research Centre, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, PO Box: 19395-4763, Tel: +98(21) 22432500, Fax: +98(21) 22416264, E-mail: hedayati47@gmail.com, hedayati@endocrine.ac.ir https://orcid.org/0000-0001-5816-775X

DOI:

https://doi.org/10.17179/excli2021-3826

Keywords:

thyroid cancers, metabolomics, metabolism, glutamine, amino acids

Abstract

Thyroid cancers (TCs) are the most prevalent malignancy of the endocrine system and the seventh most common cancer in women. According to estimates from the Global Cancer Observatory (GCO) in 2020, the incidence of thyroid cancer globally was 586,000 cases. As thyroid cancer incidences have dramatically increased, identifying the most important metabolic pathways and biochemical markers involved in thyroid tumorigenesis can be critical strategies for controlling the prevalence and ultimately treatment of this disease. Cancer cells undergo cellular metabolism and energy alteration in order to promote cell proliferation and invasion. Glutamine is one of the most abundant free amino acids in the human body that contributes to cancer metabolic remodeling as a carbon and nitrogen source to sustain cell growth and proliferation. In the present review, glutamine metabolism and its regulation in cancer cells are highlighted. Thereafter, emphasis is given to the perturbation of glutamine metabolism in thyroid cancer, focusing on metabolomics studies.

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Published

2021-07-12

How to Cite

Abooshahab, R., Hooshmand, K., Razavi, F., Dass, C. R., & Hedayati, M. (2021). A glance at the actual role of glutamine metabolism in thyroid tumorigenesis . EXCLI Journal, 20, 1170–1183. https://doi.org/10.17179/excli2021-3826

Issue

Vol. 20 (2021)

Section

Review articles

License

Copyright (c) 2021 Raziyeh Abooshahab, Kourosh Hooshmand, Fatemeh Razavi, Crispin R. Dass, Mehdi Hedayati

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