The impact of physical activity on cardiovascular mortality in the general population

Authors

  • Tetsuya Takahashi Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan https://orcid.org/0000-0002-0265-031X
  • Tetsu Watanabe Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida- Nishi, Yamagata, 990-9585, Japan, Phone: +81-23-628-5302; Fax: +81-23-628-5305; E-mail: tewatana@med.id.yamagata-u.ac.jp https://orcid.org/0000-0002-4565-3799
  • Harutoshi Tamura Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Satoshi Nishiyama Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Hiroki Takahashi Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Takanori Arimoto Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Tetsuro Shishido Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Kazunobu Ichikawa Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Sumito Inoue Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Tsuneo Konta Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan https://orcid.org/0000-0001-7681-6469
  • Yoshiyuki Ueno Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan https://orcid.org/0000-0001-5623-4250
  • Takeo Kato Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
  • Takamasa Kayama Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
  • Masafumi Watanabe Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan https://orcid.org/0000-0002-8672-7483

DOI:

https://doi.org/10.17179/excli2021-3818

Keywords:

physical activity, cardiovascular mortality, general population

Abstract

The beneficial effect of moderate physical activity (PA) on morbidity and mortality has been observed in the general population. However, the ideal intensity of PA for improving cardiovascular longevity in Japanese general population is uncertain. The aim of this study was to investigate the relationship between the PA and cardiovascular mortality in the general population. This longitudinal cohort study included 1,826 apparently healthy subjects who participated in a community-based health checkup. There were 31 cardiovascular deaths during 10-year follow-up. Subjects were divided into 4 groups based on the quartiles of PA (low, mild, moderate and high). Kaplan-Meier analysis and multivariate Cox proportional hazard analysis demonstrated that the most favorable cardiovascular prognosis was observed in subjects with moderate PA followed by those with mild PA. High PA as well as low PA were associated with higher cardiovascular mortality compared with mild and moderate PA. Noteworthy, in subjects with high PA, Cox hazard analysis revealed that previous cardiovascular disease, smoking, brain natriuretic peptide levels, and Framingham risk score were associated with cardiovascular mortality. The results suggest a U-shaped association between cardiovascular mortality and PA. Mild to moderate PA was associated with favorable cardiovascular outcomes in the Japanese general population. High PA might be associated with poor cardiovascular outcomes in subjects with a history of heart disease and high coronary risk factors.

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Published

2021-08-06

How to Cite

Takahashi, T., Watanabe, T., Tamura, H., Nishiyama, S., Takahashi, H., Arimoto, T., … Watanabe, M. (2021). The impact of physical activity on cardiovascular mortality in the general population. EXCLI Journal, 20, 1294–1304. https://doi.org/10.17179/excli2021-3818

Issue

Vol. 20 (2021)

Section

Original articles

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Copyright (c) 2021 Tetsuya Takahashi, Tetsu Watanabe, Harutoshi Tamura, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Kazunobu Ichikawa, Sumito Inoue, Tsuneo Konta, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Masafumi Watanabe

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