Diabetes is associated with higher mortality and severity in hospitalized patients with COVID-19

Authors

  • Fatemeh Moghaddam Tabrizi Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran; Khoy University of Medical Sciences, Khoy, Iran https://orcid.org/0000-0001-5273-7264
  • Yousef Rasmi Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran; Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  • Elyas Hosseinzadeh Department of Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, Iran. Tel & Fax: +983442234513; Postal cod: 7816883333; E-mail: elyas.hosseinzadeh@gmail.com https://orcid.org/0000-0002-0967-1279
  • Sakineh Rezaei Ayatoollah Khoyi Hospital, Khoy University of Medical Sciences, Khoy, Iran
  • Mohadeseh Balvardi Instructor of Biostatistics, Sirjan School of Medical Sciences, Sirjan, Iran https://orcid.org/0000-0001-7321-7292
  • Mohammad Reza Kouchari Ayatoollah Khoyi Hospital, Khoy University of Medical Sciences, Khoy, Iran
  • Ghasem Ebrahimi Department of Biochemistry and Clinical Laboratories, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Tel: +98936 273 3850; E-mail: gheb67@gmail.com, ebrahimigh@tbzmed.ac.ir. https://orcid.org/0000-0003-3492-7480

DOI:

https://doi.org/10.17179/excli2021-3403

Keywords:

diabetes, comorbidity, inflammation, mortality, COVID-19

Abstract

As a novel cause of pneumonia, coronavirus disease 2019 (COVID-19) has rapidly progressed worldwide. Previous studies have indicated COVID-19 patients with diabetes show higher mortality rates and more severe COVID-19 infection with an increased requirement for intensive care and hospital length of stay (LOS) compared to non-diabetic patients. The present study aimed to investigate the association of diabetes and COVID-19 outcome with severity of disease in hospitalized patients. The present case-control study included 268 patients diagnosed with COVID-19 who were hospitalized in Ayatollah Khoyi Hospital, Khoy, Iran. Diabetes was identified based on medical history and/or criteria of published documents. Out of 268 patients (median age of 59 years; 53.4 % male), 127 patients had diabetes (47 %). Diabetic patients had remarkably higher mortality rates (adjusted odds ratio, aOR: 3.36; confidence interval, CI: 1.17–9.66), requirement for invasive mechanical ventilation (IMV) (aOR: 4.59; CI: 1.38–15.25), and LOS (aOR: 1.13; CI: 1.06–1.24) compared to patients without diabetes. Inflammatory biomarkers including C-reactive protein (CRP), lactate dehydrogenase (LDH), and erythrocyte sedimentation rate (ESR) were increased in patients with diabetes compared to non-diabetic patients (P < 0.05 for all the comparisons). In hospitalized patients with COVID-19, diabetes was correlated with increased disease severity and mortality.

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Published

2021-02-22

How to Cite

Moghaddam Tabrizi, F. ., Rasmi, Y. ., Hosseinzadeh, E. ., Rezaei, S. ., Balvardi, M. ., Kouchari, M. R. ., & Ebrahimi, G. (2021). Diabetes is associated with higher mortality and severity in hospitalized patients with COVID-19 . EXCLI Journal, 20, 444–453. https://doi.org/10.17179/excli2021-3403

Issue

Vol. 20 (2021)

Section

Original articles

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Copyright (c) 2021 Fatemeh Moghaddam Tabrizi, Yousef Rasmi, Elyas Hosseinzadeh, Sakineh Rezaei, Mohadeseh Balvardi, Mohammad Reza Kouchari, Ghasem Ebrahimi

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