Role and application of stem cells in dental regeneration: A comprehensive overview

Authors

  • Armin Soudi Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Mohsen Yazdanian Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran, Phone: +989122937539, Fax: +982182482549; E-mail: myazdaniandr@gmail.com https://orcid.org/0000-0003-0023-6606
  • Reza Ranjbar Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Hamid Tebyanian Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran, Phone: +989198045743, Fax: +982182482549, E-mail: tebyan.hamid@yahoo.com https://orcid.org/0000-0002-5647-637X
  • Alireza Yazdanian Department of Veterinary, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Elahe Tahmasebi Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Ali Keshvad Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Alexander Seifalian Nanotechnology and Regenerative Medicine Commercialization Centre (Ltd), The London Bioscience Innovation Centre, London, UK

DOI:

https://doi.org/10.17179/excli2021-3335

Keywords:

dental, stem cells, regeneration, stem cell therapy

Abstract

Recently, a growing attention has been observed toward potential advantages of stem cell (SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now considered excellent candidates for tissue replacement therapies and tissue engineering. Autologous MSCs importantly contribute to the state-of-the-art clinical strategies for SC-based alveolar bone regeneration. The donor cells and immune cells play a prominent role in determining the clinical success of MSCs therapy. In line with the promising future that stem cell therapy has shown for tissue engineering applications, dental stem cells have also attracted the attention of the relevant researchers in recent years. The current literature review aims to survey the variety and extension of SC-application in tissue-regenerative dentistry. In this regard, the relevant English written literature was searched using keywords: “tissue engineering”, “stem cells”, “dental stem cells”, and “dentistry strategies”. According to the available database, SCs application has become increasingly widespread because of its accessibility, plasticity, and high proliferative ability. Among the growing recognized niches and tissues containing higher SCs, dental tissues are evidenced to be rich sources of MSCs. According to the literature, dental SCs are mostly present in the dental pulp, periodontal ligament, and dental follicle tissues. In this regard, the present review has described the recent findings on the potential of dental stem cells to be used in tissue regeneration.

Published

2021-02-22

How to Cite

Soudi, A. ., Yazdanian, M., Ranjbar, R. ., Tebyanian, H., Yazdanian, A. ., Tahmasebi, E. ., … Seifalian, A. . (2021). Role and application of stem cells in dental regeneration: A comprehensive overview. EXCLI Journal, 20, 454–489. https://doi.org/10.17179/excli2021-3335

Issue

Section

Review articles

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