Coagulopathy is associated with multiple organ damage and prognosis of COVID-19

Authors

  • Rui Zhang Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China
  • Yani Liu Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China
  • Bei Zhang College of Public Health, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China
  • Congqing Wu Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, KY40536, USA
  • Jinping Zhou Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China
  • Yu Zhang Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China
  • Wei Yang Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China
  • Zhenyu Li Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, KY40536, USA, E-mail: zhenyuli08@uky.edu https://orcid.org/0000-0001-7245-7200
  • Shaojun Shi Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, PR China; Phone: +86-13971292838; Fax: +86-027–8572–6192; E-mail: sjshicn@163.com http://orcid.org/0000-0002-4942-4360

DOI:

https://doi.org/10.17179/excli2020-2853

Keywords:

COVID-19, coagulopathy

Abstract

Mortality rate is high with COVID-19. Multiple organ damage is a common and lethal complication of the severe COVID-19 patients. Of 198 recruited participants, 65 patients (32.8 %) had coagulopathy. In this retrospective study, we analyzed the association of coagulopathy with organ dysfunction in hospitalized COVID-19 patients. The incidence of coagulopathy was associated with increased odds of acute liver injury, renal dysfunction and acute respiratory distress syndrome (ARDS) by multivariable regression. Overall mortality was 65 % for the patients with coagulopathy and 3.76 % for the patients without coagulopathy. History of hypertension, leukocytosis and elevated CRP concentrations were associated with higher odds of coagulopathy. Patients with coagulopathy had similar levels of hepatic and renal functional enzymes prior to the onset of coagulopathy as the patients without coagulopathy, suggesting that coagulopathy is an association of the progression of multi-organ dysfunction in COVID-19. Plasma IL-6 was higher in patients with coagulopathy than controls, but it’s not a risk factor for organ dysfunction by logistic regression. The present study shows that coagulopathy, overt DIC and non-overt DIC, associates with organ dysfunction and higher mortality rate in COVID-19. Thus, anticoagulant therapy may prevent organ dysfunction and increase survival rate in COVID-19.

Downloads

Published

2021-01-25

How to Cite

Zhang, R., Liu, Y., Zhang, B., Wu, C., Zhou, J., Zhang, Y., … Shi, S. (2021). Coagulopathy is associated with multiple organ damage and prognosis of COVID-19. EXCLI Journal, 20, 174–191. https://doi.org/10.17179/excli2020-2853

Issue

Vol. 20 (2021)

Section

Original articles

License

Copyright (c) 2021 Rui Zhang, Yani Liu, Bei Zhang, Congqing Wu, Jinping Zhou, Yu Zhang, Wei Yang, Zhenyu Li, Shaojun Shi

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).

Most read articles by the same author(s)